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KMID : 0848120170420040175
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International Journal of Oral Biology
2017 Volume.42 No. 4 p.175 ~ p.181
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The Effect of 1-Propanol on the Rotational Mobility of n-(9-Anthroyloxy) stearic acid in Outer Monolayers of Neuronal and Model Membranes
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Ahn Tae-Young
Jin Seong-Deok
Yang Hak-Jin
Yoon Chang-Dae
Kim Mi-Kyung
An Taek-Kyung
Bae Young-Jun
Seo Sang-Jin
Kim Gwon-Su
Bae Moon-Kyoung
Bae Soo-Kyoung
Jang Hye-Ock
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Abstract
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The aim of this study was to provide a basis for the molecular mechanism underlying the pharmacological action of ethanol. We studied the effects of 1-propanol on the location of n-(9-anthroyloxy)palmitic acid or stearic acid (n-AS) within the phospholipids of synaptosomal plasma membrane vesicles (SPMV). The SPMV were isolated from the bovine cerebral cortex and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL). 1-Propanol increased the rotational mobility of inner hydrocarbons, while decreasing the mobility of membrane interface, in native and model membranes. The degree of rotational mobility varied with the number of carbon atoms at positions 16, 12, 9, 6 and 2 in the aliphatic chain of phospholipids in the neuronal and model membranes. The sensitivity of increasing or decreasing rotational mobility of hydrocarbon interior or surface by 1-propanol varied with the neuronal and model membranes in the following order: SPMV, SPMVPL and SPMVTL.
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KEYWORD
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1-propanol, Fluorescence quenching technique, Rotational mobility, Hydrocarbon interior, Membranes interface
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